The Science

What is PDRN?

PDRN — Polydeoxyribonucleotide — is a skincare ingredient derived and purified from salmon DNA fragments. Inspired by Korean clinic protocols developed over the past 20+ years, it's now formulated at gentle, daily-use concentrations for at-home skincare.

3D illustration of PDRN molecules absorbed by the skin's surface — PDRN molecules — a key actor in our barrier-supporting formulas.

How it works.

PDRN is known to interact with the skin's A2A receptors, which research links to the skin's natural renewal pathways. In topical skincare, it's used to support the look of plumper, more even, and more resilient-feeling skin over time.

Why Korean skincare loves it.

PDRN has been a fixture in Seoul's top aesthetic clinics for two decades, often used in post-procedure care routines because of how comfortable and non-irritating it feels on freshly treated skin. We translated that legacy into a serum you can use at home, every day.

*These statements have not been evaluated by the Food and Drug Administration. HydroSaeng products are cosmetics and are not intended to diagnose, treat, cure, or prevent any disease.

Who it's for.

✦Skin showing fine lines, dullness, or loss of firmness
✦Dark spots and uneven tone you can't seem to fade
✦Sensitive skin that reacts to retinol
✦Anyone who wants results without irritation

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